undiscovered susceptibility loci that can be more easily discovered and characterized by annotating SNPs with information on eQTL scores. This is also a novel observation. Moreover, use of information on expression appears to benefit our understanding of not only more tractable disorders, such as Crohn's disease and autoimmune disorders, for which relatively large numbers of loci have already been identified at the cost of genotyping 10,000 or fewer samples, but also for less tractable disorders such as hypertension and bipolar disease, for which fewer associations have been characterized despite the large numbers of genotyped samples (>29,000 in GWAS and >34,000 for replication in studies of hypertension [17]).
