(Shin et al., 2007). Similarly, both overexpression and RNAi knockdown of SPIN90 decreased synaptic vesicle endocytosis (Kim et al., 2005). Recently, SNX27 was found to form a tripartite complex with β-Pix, which associated directly with SNX27, and indirectly with a G protein-coupled receptor kinase interacting protein (Git1) (Valdes et al., 2011). Both dimerization and multimeric protein complex formation offer intriguing mechanisms to regulate GIRK channel trafficking through altered SNX27 expression in vivo and remain an exciting area for future investigation.
