In summary, this study identified no differences in hippocampal volume by APOE status in those under the age of 60 and then accelerated hippocampal volume loss in ε4/ε4 carriers compared to ε3/ε3 carriers starting at age 61, and in ε3/ε4 carriers at age 69. Conversely, we observed reduced volume loss in ε2/ε3 carriers beginning at age 76. These findings underscore the critical role of age in modifying the impact of the APOE status on brain structure and carry significant clinical implications for screening and potential prevention of AD.
