at known loci, whereas under the hypothesis that the genomic inflation is consistent with polygenic inheritance and that there are multiple variants at the same loci segregating in the population, we would expect to see what we found empirically. The GIANT conditional meta-analysis detected 16 loci with additional associated SNPs, and we identified 20 more such loci, which is partly because the GIANT conditional meta-analysis used only a subset of the discovery sample (106,336 out of 133,653 individuals) due to the difficulty of managing the large number of participating studies in a fixed time period and partly because the GIANT conditional meta-analysis implemented a double-GC correction that substantially reduced the power of detection.
