suggesting that specific genetic risk factors could be identified. Indeed, the chromosome 15q25 locus described above has been associated with successful quitting in pregnant women (Freathy et al, 2009). However, many of the genetic loci affecting quitting are likely to be distinct from genetic determinants of nicotine dependence (Maes et al, 2004; The Tobacco and Genetics Consortium, 2010; Thorgeirsson et al, 2010).