Chunk #57 — MATERIALS AND METHODS — QC and association testing — Association testing

Source

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.

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For additional array-based replication analyses of the 20 discovered CNVRs in a sample of 281 independent obesity trios, intensity values for each involved marker were again extracted with the R-package ‘affxparser’. As for the family-based discovery GWAS sample, the CNV-FBAT methodology was applied to the raw intensities afterwards. Finally, one-sided P-values were calculated by taking into account the estimated CNVR effect direction as based on the family-based discovery GWAS sample.