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Chunk #36 — Discussion

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Imputation across genotyping arrays for genome-wide association studies: assessment of bias and a correction strategy.
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for any pair-wise set of arrays, strongly suggesting that the observed bias among the imputed SNPs is due to the imputation process rather than differences in genotyping quality. Moreover, it is clear from these studies that the degree of bias in a common set of SNPs imputed based on the union of genotyped SNPs from different arrays is too great to permit reliable analyses if left uncorrected.