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Chunk #24 — METHODOLOGICAL ISSUES — Study Design

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Personality and depression: explanatory models and review of the evidence.
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depression). In contrast, developmental sequencing but less shared genetic (or other etiological) variance would support the predisposition model. Also crucial for the predisposition model is evidence from longitudinal studies demonstrating that other variables (e.g., life stress) moderate or mediate the association between personality and subsequent depression.