Lastly, we observed two distinct patterns of functional connectivity alterations that separated patients with mTLE from healthy controls on the one hand and that predicted better and worse episodic memory performance within this patient population on the other hand. These patterns might be best described as (1) a posterior interhemispheric network that integrates the MTL into the posterior part of the DMN and that was stronger in healthy controls and associated with better episodic memory capacity in patients and (2) an anterior intrahemispheric network that connects the prefrontal cortex with other parts of the DMN and that was stronger in patients with mTLE and associated with worse episodic memory capacity in them. While none of the current literature speaks to this distinction directly, a number of recent observations allows for some speculation. For example, recruitment of the posterior parts of the DMN and connectivity between them have been implicated in episodic memory retrieval, whereas recruitment of the anterior parts (i.e., prefrontal cortices) and connectivity between prefrontal and posterior cingulate cortices have been implicated in semantic memory retrieval (Shapira-Lichter et al.,
