In the discovery meta-analyses, we identified 15 common SNVs that were genome-wide significant (P < 5 × 10-8) for one or more of the smoking behaviour traits, of which 9 were novel (Table 1, Supp. Table 3). Seven novel loci were identified for smoking initiation, one for both CPD and pack-years and one for smoking cessation (Figs. 1, 2, Table 1 and Supp. Figure 1). Results for the significant loci were consistent across participating cohorts and there was at least nominal evidence of association (P < 0.05) at the novel loci within each of the contributing consortia (Supp. Table 4). Full association results for all novel SNVs across the four traits are provided in Supp. Table 5. No rare variants were genome-wide significant; the rare variant with the smallest P-value was a missense variant in ATF6, rs141611945 (MAF < 0.0001, CPD P = 2.95 × 10−7).
