In conclusion, while the associations detected in the present study are not significant after taking into account multiple testing, multiple studies reporting associations between ALDH1A1 and alcohol-related phenotypes have been published recently, and our results provide further evidence for a role of ALDH1A1 in the risk for problem alcohol consumption behaviour and possibly alcohol dependence. With this in mind, our findings need to be replicated in a larger Finnish or Caucasian population and a systematic search for, and genotyping of, additional ALDH1A1 variants that influence alcohol-related phenotypes is warranted.
