percent of control children manifested externalizing psychopathology at follow-up. Sensitivity analyses indicated that moderation of the Fast Track intervention effect on externalizing psychopathology at age 25 years by rs10482672 genotype was primarily due to increased effectiveness of the intervention in preventing alcohol abuse and ADHD in rs10482672 “A” allele carriers. Genetic moderation of intervention effects was observable already during adolescence. Across assessments spanning grade 7 through two years post-high school, Fast Track intervention was associated with lower levels of self-reported delinquency, alcohol use, and cannabis in children who carried an rs10482672 “A” allele, but not in their peers who did not carry an “A” allele. None of the NR3C1 SNPs genotyped in our study showed evidence of moderating Fast Track intervention response in African-American children.
