Early-onset exposure to tobacco and nicotine - even the first experiments followed by development up to daily use in adolescence – should be recognized as a potential warning sign for later SRB. Female vulnerability for SRB suggests implications for designing prevention programs promoting young women’s mental health. However, we should take into consideration that in young adulthood, males in general are at highest risk for suicide and, perhaps, are less likely to report risk behaviors and seek help. Further investigation may reveal whether this association has implications for prevention of SRB in adolescence and young adulthood.