adequately powered, a topic we consider at length in subsequent sections. In addition, any molecular genetic finding must be supported through replication or meta-analysis. Once this is established, conducting investigations to determine if the same variants are associated with the relevant clinical phenotype should be relatively straightforward if power is also adequate. This accomplishment would speak directly to the hoped-to-be-realized promise of endophenotypes. However, and importantly, it is conceivable that this process would also work in reverse in that genetic variants associated with a clinical phenotype can be used to identify variants for an electrophysiological measure with which it is correlated.
