Chunk #37 — Results — Determinants of GWAS power and PGS R2 — CGR between sets of studies

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.

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1k causal SNPs, a CGR of one within each cluster, and CGR of zero between clusters, the power is expected to be 49%, which is identical to the power of a meta-analysis of either the first or the second cluster. However, if the CGR between clusters is 0.5 instead of zero, the power goes up to 58%. In terms of the expected number of hits, this cross-ancestry meta-analysis yields an expected 82 additional hits, compared to a meta-analysis considering only one ancestry.