The alcohol dependent group showed less response in the lateral OFC, mPFC, DLPFC, and VS (anteroventral caudate region, extending into dorsal caudate) than the comparison group to win vs. loss (Table 2; Figure 2). The alcohol dependent group did not exhibit greater response than the comparison group in any of the ROIs. The groups did not differ in medial OFC response. There were no sex differences in neural response. Whole-brain results for group differences confirmed that these ROIs were critical regions in which the groups differed (Table S1).