elevate 2-AG in vivo (King et al., 2007) and has similar selectivity for both MAGL and FAAH (Vandevoorde et al., 2007). However, JZL184 (Long et al., 2009) potently inhibits MAGL in vivo and is highly selective (200-fold higher for MAGL than for FAAH) and long lasting (> 24 h). Systemic administration of JZL184 significantly increases anandamide in mouse brain and spinal cord and has antihyperalgesic and anti-allodynic effects (Kinsey et al., 2009; Long et al., 2009).
