The Phase I HapMap data have been used to identify genomic regions that show evidence for the influence of adaptive evolution3,9, primarily through extended haplotype structure indicative of recent positive selection. Using two established approaches9,44, we identified approximately 200 regions with evidence of recent positive selection from the Phase II HapMap (Supplementary Table 9). These regions include many established cases of selection, such as the genes HBB and LCT, the HLA region, and an inversion on chromosome 17. Many other regions have been previously identified in HapMap Phase I including LARGE, SYT1 and SULT1C2 (previously called SULT1C1). A detailed description of the findings from the Phase II HapMap is published elsewhere45.
