Chunk #68 — Methods — Evolutionary genetics of individuals with diverse ancestry — Rare variant sharing

Source

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

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To confirm that J is not biased by sample size, we randomly sampled 500 individuals from each of two studies with European (AFGen and FHS) and African (COPDGene and JHS) population groups in TOPMed freeze 3, without replacement. We then recalculated J between and within these randomly sampled studies, considering alternative allele counts between 2 and 100 within these 2,000 individuals.