To demonstrate the potential for mash to provide novel insights, we apply it to analyze cis eQTL effects in 16,069 genes across 44 human tissues. Focusing on the strongest cis eQTLs, we find that while most eQTLs are shared by many tissues, effect sizes can still vary considerably. Our results suggest that when assessing effects that are “tissue-specific” versus “tissue-consistent”, we should pay careful attention to the sizes of effects, and not only the tests for significance.
