Chunk #17 — MATERIALS AND METHODS — 3-D visualization of RYRs and BK channels

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Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes.

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As shown in the Results, positive immunostained objects for RYRs and BK channels consist of multiple voxels. We call this group of voxels a punctum. Our functional analyses revealed that each punctum is made of multiple channels, and we call all of the channels in a punctum a cluster.