Once a candidate gene list is available, it is useful to be able to efficiently access the underlying literature, and to generate a list of deleterious SNPs in the genes of most interest. As an example of this process, we consider one of the pre-built disease candidate lists, for hypertension. Clicking on the disease returns a list of the candidate genes, ranked by confidence of disease relevance, based on profile overlap with the disease. Table 3 shows the top part of the list. Highest ranked are well known hypertension-related genes, for example, angiotensinogen (AGT) and angiotensin I converting enzyme (ACE). Each gene in the list is linked directly to local copies of the relevant abstracts, with color highlighting of appropriate words, so that a user may very rapidly assess the evidence for candidate status. There are also links to OMIM [49] and the NIA genetic association database information[47], providing sources of expert information on disease relevance.
