An overview of the p-values for the trio analysis plotted against genomic location is illustrated in Figure 2a. Of the top 4 OCD-associated SNPs in the trio sample with p-values< 1 × 10-5, one SNP, rs6131295 (11,996,267bp (hg19) on 20p12.1-2), exceeded the threshold for genome-wide significance of p<5×10-8 with a p=3.84×10-8.57 This SNP is located ∼90 kb 3′ to BTBD3 (Figure 3). None of the other 442 SNPs with p-values<0.001 were in LD (r2>0.2) with this SNP (Supplementary Table S2).
