Over the last decade animal models of long latency event-related potentials have been developed in order to further explore the behavioral, neuroanatomical and neurochemical basis of the ERP components (see O’Brien, 1982; Harrison & Buchwald, 1985; Paller et al., 1988; Takeuchi et al., 2000). With the rapid advances in molecular genetic techniques many investigators are using mice as subjects. The use of “knock-outs”, transgenics, as well as inbred selected line approaches have established mouse models as very powerful in studies aimed at uncovering the neurobiological basis of behavior and cognitive function (Campbell, 1995; Wehner et al., 1996; Price et al., 1998; Brusa, 1999; Ingram & Jucker, 1999; Sturchler-Pierrrat & Sommer, 1999). While evoked potentials are commonly recorded in mice, ERP paradigms for use in generating late wave responses have been little reported (see Ehlers & Somes, 2002; Siegel et al., 2003; Umbricht et al., 2005). The present study was undertaken to further develop a model of mouse EROs using auditory stimuli. EROs were generated in a paradigm shown to produce P3-like ERP components (Ehlers & Somes, 2002). We previously demonstrated
