that enables appropriate responses to stimuli previously shown for macrophages (Gosselin et al., 2014; Lavin et al., 2014)(further reviewed in (Glass and Natoli, 2016). Lastly, a TGFβ-dependent homeostatic microglia signature was identified that paralleled murine studies and highlight that AD GWAS genes function in microglia homeostasis. Taken together, our studies emphasize the importance of microglia in AD risk and the utility of iMGLs to interrogate genotype-phenotype relationships of recent AD GWAS single nucleotide polymorphisms.
