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Chunk #4 — Materials and Methods — IMPUTE2 algorithm

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Genotype imputation with thousands of genomes.
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yes

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Howie et al. (2009) used the surrogate family approximation to speed up the phasing updates in IMPUTE2 (Step 1 of the MCMC algorithm described above), but they used all available reference haplotypes for the imputation updates (Step 2). To make computation faster in large, ancestrally diverse reference panels, we now extend the approximation to imputation updates.