by exponential enrichment (SELEX) and computational approaches [18-22]. In addition, DNA microarrays and polymerase colony approaches have been developed for higher-throughput analysis of alternative mRNA isoforms [23-26] and a cross-linking/immunoprecipitation strategy (CLIP) has been developed for systematic detection of the RNAs bound by a given splicing factor [27]. These new methods suggest a path towards increasingly parallel experimental analysis of splicing regulation.
