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Chunk #34 — Results — Impact of Per3 on downstream gene expression and function

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A promoter polymorphism in the Per3 gene is associated with alcohol and stress response.
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To confirm potential Per3 downstream targets, we compared expression levels between wild type and homozygous Per3 KO mice. We found 2217 differentially expressed genes (P<0.05), seven of which (Cast, Trpm2, Anks1b, Gpr81, Hsbp1, Pdlim5 and 4930528J18Rik) are also among the 48 transcripts with trans QTLs near Per3.