Members of D4-only were less likely to be diagnosed with other psychiatric (e.g., conduct disorder, major depression, etc.) and substance use disorders relative to those in D4D5, suggesting a less severe phenotype generally. However, the “loss” of these individuals is offset by the addition of D5-only, among whom other psychiatric/ substance use diagnoses are also less common relative to D4D5. Age of onset of AUD symptoms was older for D5-only than for D4-only and D4D5; both D4-only and D5-only reported lower “maximum drinks in 24 hours” than D5-only. For some disorders (e.g., opiate abuse/dependence diagnosis), prevalence is quite low, and these findings should be considered preliminary given the small sample sizes of D4-only and D5-only.
