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Chunk #25 — Variance explained by SNPs within identified loci

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A saturated map of common genetic variants associated with human height.
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to all well-imputed common SNPs (that is, beyond the HM3 panel) and found, consistently across population groups, that although more genetic variance can be explained by common SNPs that are not included in the HM3 panel, all information remains concentrated within these 7,209 GWS loci (Extended Data Fig. 6). Thus, with this large GWAS, nearly all of the variability in height that is attributable to common genetic variants can be mapped to regions comprising around 21% of the genome. Further work is required in cohorts of non-European ancestries to map the remaining 5–10% of the SNP-based heritability that is not captured within those regions.