All participants included in the analyses were drawn from the customer base of 23andMe, Inc., a consumer genetics company. Participants provided informed consent and answered surveys online under a protocol approved by Ethical and Independent Review Services, an independent AAHRPP-accredited institutional review board (http://www.eandireview.com). We restricted the original sample (~25,000 individuals) to a set of unrelated participants of European ancestry (>97% as determined through an analysis of local ancestry [Durand, Do, Mountain & Macpherson 2014]; see Supplementary for additional details) for whom AUDIT data were available. Participants were not administered AUDIT if they reported that they never drank alcohol (N = 1,376; ‘Alcohol use’ questionnaire, Supplementary Table 1). The final number of participants included in the analysis was 20,328. Recruitment occurred over an approximately four-month period in 2015. Sociodemographic details are described in the Supplementary Table 1.
