CIMPR with the TGN marker protein, TGN46. It is not likely, however, that enhanced retromer function through TBC1D5 inhibition would markedly increase the levels of TGN-localised retromer cargo proteins as this would require increased production of transport intermediates and elevated docking and fusion of these intermediates with the TGN, and loss of TBC1D5 appears to enhance retromer function only at the endosome.
