as the activator of diathesis, as indexed by the Val158Met polymorphism in COMT to predict psychosis outcomes at age 26. For schizophreniform disorder, the odds-ratios reflecting the association with adolescent cannabis use were 10.9, 2.5 and 1.1 in the Val/Val, Val/Met and Met/Met (Met for Methionine) individuals respectively. Similar effects were seen for hallucinations and delusions, however when adult-onset cannabis use was examined, no significant associations were noted for any of the psychotic outcomes. Furthermore, presence of the Val allele was not associated with increased or decreased likelihood of adolescent cannabis exposure.
