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Chunk #14 — Methods — Statistical analyses

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Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms.
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All analyses were stratified by sex and clustered by family to account for relatedness. Primary analyses examined discrete childhood trauma variables (CPAT, CSAT, CNAT) as predictors of intercept and slope of EEGc (alpha EEG inter- and intra-hemispheric coherence) during adolescence and young adulthood using latent growth curve models (LGCM) for those with three or more EEG assessments. We ran the LGCM models in Mplus version 8.9 (Muthén & Muthén, 1998-2017), which employs full information maximum likelihood to account for missing data. A non-response analysis indicated that individuals who did not return for follow-up were younger (OR: 2.1, p < 0.001) and less likely to report a prior non-assaultive trauma (OR: 1.3, p < 0.001). No significant differences regarding sex, race/ethnicity, sexual and assaultive trauma exposure, or EEGc were observed. EEGc from bipolar pairs at three frontal sites (Fig. 2), left intra-hemispheric frontal-central (LFC: FZ-CZ--F3-C3), right intra-hemispheric frontal-central (RFC: FZ-CZ--F4-C4), and prefrontal inter-hemispheric (PFI: F8-F4--F7-F3) were examined in separate models. We modeled both linear and quadratic growth components for EEGc. The models that included the quadratic term did not converge, thus we moved ahead with a linear slope term. Any mention of slope in the following sections refer to linear slope.