The finding that the alcohol dehydrogenases genes were significantly associated with the smoking behavior EVNV in this analysis (e.g., ADH4 gene-level P = 0.048 (rs3828541), and ADH6, gene-level P = 0.034 (rs3857224) suggests that genetic variation at these ADH loci may influence the establishment of smoking behavior. However this analysis did not control for alcohol consumption and so this finding should be considered preliminary.
