1,279 additional European-ancestry controls were obtained through the Database of Genotypes and Phenotypes (dbGaP) from the Studies of Addiction: Genetics and Environment (SAGE) cohort.20 SAGE controls were excluded for lifetime substance dependence but were not screened for other psychopathology. The SAGE controls were genotyped on the Illumina Human-Hap1Mv1_C (referred to here as ‘Hap1M controls’).