medications. All participants in the trial provided informed consent for both genotyping and treatment; however, at the time of this genotyping analysis, samples remained for 534 subjects. Analyses were limited to individuals of European ancestry with both phenotype and genotype data (n = 412). Although we examine population structure within all 534 individuals of differing self-identified ethnicities, we limit our primary analyses to only those individuals who self-identified as Caucasian because of the potential for differential linkage disequilibrium across ethnic groups to lead to heterogeneity of effect estimates.
