The gene is expressed in many tissues including brainrs10421632Additive9.68E-061962456582Within 25 kb downstream of AURKC1Inattentive symptom countrs10227331Recessive3.79E-067156987699Within 40 kb of PTPRN2Encodes protein tyrosine phosphatase, receptor type, N polypeptide 2, a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRN2 shows especially high expression in brain. Lies within linkage region for autism observed in meta-analysis (Trikalinos et al. 2006). In addition, the gene showed association in GWAS of schizophrenia (Sullivan et al. 2008) and of bipolar disorder (Sklar et al. 2008) at P = 10−4 rs2769967Recessive3.63E-06981079178IntergenicClose to meta-analytic suggestive linkage region for ADHD (Zhou et al. 2008c)rs1471225Additive8.09E-061527675688Within 30 kb downstream of KIAA0574Encodes protein of unknown function expressed in brain and other tissues. Finding lies within meta-analytic suggestive linkage region for ADHD (Zhou et al. 2008c). The gene is found in CNV regions in 3 studies of autism (Christian et al. 2008; Marshall et al. 2008; Sebat et al. 2007)Site known for CNVs rs7172689 Additive3.86E-061579320750Within intron of IL16Encodes interleukin 16. The protein is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor
