Chunk #15 — 2. Experimental Section — 2.3. Analytic Plan — 2.3.1. Genome-Wide Association Analysis in the ALSPAC Sample

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Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment.

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The GWAS was conducted using MACH2QTL [37] and was limited to individuals of European descent. Sex was included as a covariate.