with the drug experience and eventually acquire the ability to increase dopamine in anticipation of reward. This dopamine signal can elicit strong motivation to pursue a drug of abuse (Owesson‚ White et al., 2009; Salamone, Correa, Farrar, & Mingote, 2007). Thus, dopamine signaling in several brain regions including the nucleus accumbens, dorsal striatum, ventral pallidum, dorsolateral prefrontal cortex, anterior cingulate, and orbitofrontal cortex modulate the motivation to pursue abused substances (Salamone, et al., 2007).
