for these variants from each of the AA, CH and HIS results. We restricted our primary discovery analysis to Europeans only after finding a lack of significant validation and concordance between EUR and non-EUR data for previously reported HR variants. As a secondary analysis, we performed look-ups of all validated novel loci within the non-European data. The forest plots for all validated novel loci display non-European results, to serve as a comparison to results within Europeans. In addition to calculating the percentage of concordance of effect directions for each ancestry compared with Europeans, a Binomial sign test was also performed in R. This test was based on the number of SNVs with consistent effect directions, and it was done to determine whether the concordance was higher than expected by chance alone, using P < 0.05 to declare significant concordance.
