Consistent with the RL-ERN’s hypothesized role of DA in the generation of the ERN, administration of the DA agonist D-amphetamine leads to an increase in the ERN amplitude (de Bruijn, Hulstijn, Verkes, Ruigt, & Sabbe, 2004), whereas the administration of the DA antagonist haloperidol leads to a decrease in the ERN amplitude (de Bruijn, Sabbe, Hulstijn, Ruigt, & Verkes, 2006; Zirnheld et al., 2004). Demonstrating the specificity of DA neurotransmitter levels on the ERN, one study found that the selective serotonin reuptake inhibitor paroxetine had no effect on ERN amplitude (de Bruijn et al., 2006).
