Of the 172 genes with Wald ratio findings in Cortex-EUR, there were 47 without a significant eQTLGen instrument, including five (RGS1, SCO2, SLC12A5, CCDC155 and MYNN) that passed the MR and co-localization significance thresholds in MetaBrain (Supplementary Note and Supplementary Table 16). In comparisons of the blood and brain expression levels of these genes in GTEx30, SLC12A5 and CCDC155 had almost no expression in blood, whereas expression was comparable between tissues for RGS1, SCO2 and MYNN (Supplementary Note and Supplementary Fig. 25). The discrepancy in MR findings observed between Cortex-EUR and eQTLGen suggest the existence of tissue-dependent genetic effects for MS.
