There is debate as to whether research should focus on the genes and SNPs implicated by GWAS, since they are common, or on the rare variants, since their effects are penetrant and thus provide more traction on the core biology. Given the proliferation of genetic findings, only a selected few (in either category) can be taken forward for experimental investigation. Different research groups are making different choices and adopting different strategies, and it remains to be seen which prove to be most successful (McCarthy et al., 2014).
