There were no differences in allele frequencies by gender [rs1391166, χ2(l) = 0.05, p = 0.83; and rs1497571, χ2(1) = 1.01, p = 0.32] or by ethnicity (rs1391166, Fisher’s exact p = 0.23; and rs1497571, Fisher’s exact p = 0.72) for either SNP. Likewise, the groups did not differ in age for either SNP, t(110) = 1.06, p = 0.29 and t(110) = −1.54, p = 0.13, respectively. Analysis of LD indicated that the D′ for SNPs 1 and 2 was 0.76, suggesting some evidence of recombination; this is also supported by the fact that the 2 SNPs were harbored in different haplotype blocks. As shown in Fig. 1, the 2 SNPs of interest in this study were found to be in high LD with polymorphisms previously studied in the context of alcoholism phenotypes.
