In summary, we observed differential gene expression patterns in high-PRS and low-PRS human microglial cells in response to intermittent ethanol exposure and heightened phagocytotic responses in the AUD high-PRS microglial cells that may affect synaptic transmission differentially than low-PRS microglial cells. These findings shed light on the multifaceted mechanisms underlying AUD and emphasize the importance of considering genetic factors when exploring microglial responses in this complex disorder.
