alpha synchrony is modulated by serotonergic projections from the raphe nuclei to the intralaminar and medial thalamic nuclei [95]. Furthermore, oscillatory activity and related behaviors are modulated by administration of antidepressant medication in animals [94], [96]–[97]. Oscillatory synchrony could represent the neurophysiologic link between neurochemical activity and brain network functions that regulate mood, affect, and processing of emotional information. Oscillatory dysregulation may similarly represent the pathophysiologic link between disturbances in monoaminergic neurotransmission and brain network dysfunction in MDD. Future research should more closely examine the regulation of oscillatory synchrony in subjects at risk for or recovering from MDD, as well as the effect of antidepressant treatments on oscillatory synchrony in MDD.
