number of differences in gene expression compared to the W control group (suggesting little effect of repeated BACs, that exceeded 50 mg% per access period, five days per week), the differences between the CA and W groups may reflect the effects of removal of the ethanol. A recent study (Bell et al., 2009) indicated significant behavioral changes (alterations in motor activity and rearing behavior) occur between 9 and 13 hr after removal of ethanol in P rats that had 24-hr continuous/daily free-choice access to ethanol for approximately 6 months. These studies suggest some behavioral alterations are occurring after removal of ethanol from P rats given continuous access, and there may be a relationship between the changes in gene expression within the ACB observed in the present study and these changes in general motor activity.
