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Chunk #88 — Methods — LD score regression

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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.
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We ran S-LDSC for all ancestry-associated DEGs and conducted separate runs for DEGs of protein-coding and noncoding genes. For cell type-specific enrichment, we used glia subpopulation specificity markers generated in ‘Single-cell specificity and cell type enrichment analysis’.