The AGES-Reykjavik Study was designed to investigate aging using a multifaceted comprehensive approach. Physical, physiological and questionnaire examinations were conducted in three visits for each subject including detailed medical history, physical examination, laboratory and screening tests, and questionnaires on health-related behaviors such as alcohol consumption, smoking history, and physical activity. Pertinent to this study, these measures included anthropometric measurements and computerized tomography measures of adipose depots in the abdomen and thigh. The AGES–Reykjavik study was approved by the institutional review boards of the National Institute on Aging and the Icelandic National Bioethics Committee (VSN: 00-063), and written informed consent was obtained from all participants.